Skip to main content

Scarred Hearts Healed After Heart Attack

Feb. 13, 2012 -- a new stem mobile treatment resurrects useless, scarred heart muscle broken through a recent heart assault.

The finding, just in time for Valentine's Day, is the clearest evidence yet that actually damaged hearts can heal. All that is wished is a little assist from one's personal coronary heart stem cells.

"We have been trying as docs for centuries to discover a remedy that clearly reverses coronary heart injury," Eduardo Marban, MD, PhD, tells WebMD. "that's what we appear to have been capable of acquire on this small number of sufferers. if so, this will change the nature of medicine. We ought to visit the root of sickness and remedy it in place of simply work around it."

Marban, director of the Cedars-Sinai coronary heart Institute in l.  a., led the examine. He invented the "cardiosphere" culture approach used to create the stem cells and founded the organization developing the treatment.

it is the primary finished, managed clinical trial displaying that scarred coronary heart tissue can be repaired. in advance paintings in patients with heart failure, the usage of distinct stem cells or bone-marrow stem cells, also showed that the coronary heart can regenerate itself.

"those findings advise that this healing technique is possible and has the ability to provide a remedy method for cardiac regeneration after [heart attack]," write university of Hong Kong researchers Chung-Wah Siu and Hung-fats Tse. Their editorial accompanies the Marban report in the Feb. 14 advance on line problem of The Lancet.

continue reading underneath
you may LIKE

better drug charges from the call you could believe.

coronary heart Regenerates With Stem cell help

The stem cells don't do what human beings suppose they do, Marban says.

it is been concept that the stem cells multiply time and again again. In time, they had been presupposed to be turning themselves and their daughter cells into new, running heart muscle.

but the stem cells appear to be doing some thing a great deal extra top notch.

"For reasons we did not first of all recognise, they stimulate the heart to restore itself," Marban says. "The repair is from the coronary heart itself and now not from the cells we provide them."

exactly how the stem cells do this is a remember of "feverish research" in Marban's lab.

The section I medical trial enrolled 25 sufferers who had just had a coronary heart attack. On common, each affected person had misplaced a quarter of his coronary heart muscle. MRI scans showed huge scars.

eight patients were given widespread care. the alternative 17 acquired growing infusions of what Marban calls stem cells. The cells have been grown inside the lab from tiny quantities of coronary heart cells taken from the sufferers' very own hearts through biopsy. Six to 12 weeks later, the cells were infused immediately back into patients' hearts.

A 12 months later, the mass of scar tissue inside the dealt with sufferers' hearts were given forty two% smaller. And wholesome heart muscle expanded by using 60%. No such regeneration become visible in the sufferers who were given general care.

because all of the patients had been doing notably nicely, there has been no dramatic distinction in scientific final results. however, dealt with patients had a chunk better exercising endurance.

"This discovery challenges the traditional information that, as soon as installed, cardiac scarring is everlasting and that, once misplaced, healthful coronary heart muscle cannot be restored," Marban and associates conclude.


Popular posts from this blog

Will Dark Chocolate a Day Keep the Doctor Away?

may additionally 31, 2012 -- have to humans at excessive hazard of coronary heart assault and stroke eat dark chocolate every day?

maybe, in line with a brand new study from Australia.

"dark chocolate can be a pleasing and effective way of turning in essential dietary additives that can offer fitness blessings to the ever growing numbers of human beings at improved threat of cardiovascular ailment," says researcher Christopher M. Reid, PhD, professor of cardiovascular epidemiology and preventive medication at Monash university in Australia.

Reid and his group built a mathematical model to are expecting the long-term health consequences of ingesting dark chocolate day by day in high-risk people. They did no longer observe actual people ingesting actual chocolate.

The researchers also computed whether or not it'd be fee-powerful to spend money on a public schooling marketing campaign approximately dark chocolate's benefits. They observed it might be.

numerous studies h…

Millions of Women Unaware They Have Arterial Disease

Feb. 15, 2012 -- among four million and five million girls within the united states have peripheral artery sickness, or PAD, but few are identified and even fewer receive good enough treatment.

In a unique file released at the midpoint of yankee coronary heart Month, the yankee heart affiliation is looking for greater efforts to pick out and diagnose girls at chance for the condition that typically affects the leg arteries, and is likewise calling for extra ladies to be concerned in PAD research.

a chief purpose is to elevate consciousness approximately a disease that tens of millions of women have, but few know approximately, says university of Minnesota clinical faculty professor of drugs, epidemiology, and network fitness, Alan T. Hirsch, MD, who changed into the lead creator of the assertion.

“The fee of dying and the fitness-care prices related to PAD are at the least akin to the ones of heart ailment and stroke,” he says.

PAD raises coronary heart, Stroke danger

Peripheral arter…

Higher BPA Levels, More Heart Disease?

Aug. 15, 2012 -- people who have better ranges of the chemical bisphenol A (BPA) in their urine may be more likely to have narrowing in their coronary arteries, a new study indicates.

BPA has been used for extra than forty years in food packaging, metal meals and beverage can liners, and lots of other products. almost all and sundry has detectable levels of BPA, says researcher David Melzer, MD, PhD, professor of epidemiology and public health at England's university of Exeter.

Melzer's new take a look at suggests an affiliation between urinary BPA stages and the width of the coronary arteries, which deliver blood to the coronary heart.

"The people who had narrowed arteries had higher ranges of BPA in their urine," Melzer says.

The look at, published in PLoS One, does not prove that BPA narrowed each person's arteries. Many factors, which includes food regimen and activity, affect coronary heart fitness.

still, Melzer says, "We need to take it severely that …